Signal Amplification Methods

Summary Signal amplification methods were initially designed as an alternative to target amplification technologies, such as polymerase chain reaction (PCR), to minimize the possibility of contamination by target amplification products. Unlike target amplification, signal amplification methods (as defined herein) do not rely on enzymes for amplification. Probe-based amplification techniques, such as cleavage-based amplification and rolling … Read more

Second Messenger System

Second messenger, a molecule within cells that acts to transmit signals from a receptor to a target. The term second messenger was coined with the discovery of these substances to distinguish them from hormones and other molecules that function outside the cell as “first messengers” in the transmission of biological information. Many second messenger molecules … Read more

Proton Pump Inhibitors

Proton-pump inhibitor Proton pump inhibitors (PPIs) are medications that work by reducing the amount of stomach acid produced by glands in the lining of the stomach. How PPIs Help You Proton pump inhibitors are used to: Relieves symptoms of acid reflux or gastroesophageal reflux disease (GERD). This is a condition in which food or liquid … Read more

Evidence of protein binding by a nucleopeptide based on a thymine-decorated L-diaminopropanoic acid through CD and in silico studies

Evidence of protein binding by a nucleopeptide based on a thymine-decorated L-diaminopropanoic acid through CD and in silico studies

Nucleopeptides are chimeric compounds of biomedical significance carrying DNA nucleobases anchored to peptide backbones with ascertained capability to bind nucleic acids. However, their capability to work together with proteins concerned in pathologies of social relevance is a function that also requires investigation. The worrying scenario at present noticed worldwide for the COVID-19 pandemic urgently requires the analysis … Read more

Current trends in flow cytometry automated data analysis software

Current trends in flow cytometry automated data analysis software

Automated flow cytometry (FC) data analysis instruments for cell inhabitants identification and characterization are more and more getting used in educational, biotechnology, pharmaceutical, and scientific laboratories. The improvement of those computational strategies is designed to beat reproducibility and course of bottleneck points in guide gating, nevertheless, the take-up of those instruments stays (anecdotally) low. Here, … Read more

Towards medical knowmetrics: representing and computing medical knowledge using semantic predications as the knowledge unit and the uncertainty as the knowledge context

Towards medical knowmetrics: representing and computing medical knowledge using semantic predications as the knowledge unit and the uncertainty as the knowledge context

In China, Prof. Hongzhou Zhao and Zeyuan Liu are the pioneers of the idea “knowledge unit” and “knowmetrics” for measuring knowledge. However, the definition on “computable knowledge object” stays controversial up to now in several fields. For instance, it’s outlined as (1) quantitative scientific idea in pure science and engineering, (2) knowledge level in the … Read more

Novel nanomaterial-organism hybrids with biomedical potential

Novel nanomaterial-organism hybrids with biomedical potential

Instinctive hierarchically biomineralized constructions of assorted organisms, reminiscent of eggs, algae, and magnetotactic micro organism, afford further safety and distinct efficiency, which endow fragile organisms with a tenacious means to adapt and survive. However, spontaneous formation of hybrid supplies is troublesome for many organisms in nature. Rapid improvement of chemistry and supplies science efficiently obtained … Read more

Cytotoxicity and Toxicological Studies of Artocarpus altilis Extracts, Inducing Apoptosis and Cell Cycle Arrest via CASPASE-3 and CASPASE-8 Pathways Against Human Breast MCF-7 Cells

Cytotoxicity and Toxicological Studies of Artocarpus altilis Extracts, Inducing Apoptosis and Cell Cycle Arrest via CASPASE-3 and CASPASE-8 Pathways Against Human Breast MCF-7 Cells

In current biomedical analysis, the world of most cancers and infectious illnesses has a number one place within the utilization of medicinal crops as a supply of drug discovery. Malaysia has a variety and a big quantity of underutilized fruits which are wealthy in phenolic compounds. Artoarpus altilis think about an underutilized fruit that’s wealthy in phenolic compounds. … Read more

“EviMass”: A Literature Evidence-Based Miner for Human Microbial Associations.

"EviMass": A Literature Evidence-Based Miner for Human Microbial Associations.

The significance of understanding microbe-microbe in addition to microbe-disease associations is without doubt one of the key thrust areas in human microbiome analysis. High-throughput metagenomic and transcriptomic tasks have fueled discovery of a lot of new microbial associations. Consequently, a plethora of knowledge is being added routinely to biomedical literature, thereby contributing towards enhancing our information on microbial associations. … Read more